The Detroit Lions are set to face the Buffalo Bills in a Week 2 “Thursday Night Football” matchup during the 2026 NFL season, marking the debut of the Bills’ new stadium. This game will feature an early test for Buffalo’s new defensive regime, following the departure of head coach Sean McDermott. The Lions, who have struggled against the Bills with five consecutive losses since 2006, will benefit from playing in September’s milder weather. This matchup will be a significant event for both teams as they navigate the new season.
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2026 Detroit Lions Schedule Released Buffalo Bills to Host Lions in Primetime
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