The 49ers ruled out wide receiver Ricky Pearsall and cornerback Renardo Green due to injuries, while activating defensive lineman Yetur Gross-Matos from injured reserve. Coach Kyle Shanahan noted Pearsall was close to returning but not ready. Additionally, the 49ers activated cornerback Eli Apple and linebacker Eric Kendricks, with several other players also listed as inactive. The Colts’ inactives include key players like cornerback Sauce Gardner and running back DJ Giddens, but they activated defensive tackle DeForest Buckner.
