Matthew Boyd struck out 10 batters and allowed two runs over 5 2/3 innings as the Chicago Cubs defeated the Los Angeles Angels 6-2. Nico Hoerner contributed three hits, while Matt Shaw added two hits and two RBIs in a decisive third inning where the Cubs scored five runs. The Angels managed two runs in the sixth, but an error by Alex Bregman led to an unearned run for Chicago in the seventh. The Cubs will face Cleveland next, while the Angels will have an off day before their home opener.

