In 2025, Phillip Rivers continues to start in prime-time games, facing the 49ers as the Colts are 5.5-point underdogs. The 49ers, motivated by their playoff positioning, are expected to exploit the Colts’ struggling secondary, especially with Rivers’ age and lack of recent playtime. Key bets include an Anytime TD for Jennings at +155 and Warren at +250, along with various player props highlighting Colts’ usage dynamics. Overall, the 49ers are favored to win convincingly against the Colts amid their four-game losing streak.
