The 49ers face the Saints in Week 2 without quarterback Brock Purdy and tight end George Kittle, both sidelined by injuries. As Mac Jones makes his first start with the team, key players to watch include linebacker Dee Winters, kicker Eddy Piñeiro, rookie safety Marques Sigle, and wide receiver Ricky Pearsall, who will be crucial for the 49ers’ offensive efforts.
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Five 49ers you should watch vs. Saints in Week 2 matchup of 2025 NFL season
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