In the betting odds for the 2025 NFL season, the 49ers are slight favorites over the Rams in the NFC West at +165, aided by a favorable schedule against last-place teams. While the 49ers finished last the previous season, their opponents include the Bears, Giants, and Browns, whereas the Rams face tougher competition from the Lions, Eagles, and Ravens, potentially impacting their standings.
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Last-place schedule gives 49ers edge over Rams in NFC West
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