In the betting odds for the 2025 NFL season, the 49ers are slight favorites over the Rams in the NFC West at +165, aided by a favorable schedule against last-place teams. While the 49ers finished last the previous season, their opponents include the Bears, Giants, and Browns, whereas the Rams face tougher competition from the Lions, Eagles, and Ravens, potentially impacting their standings.
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As the 49ers report to training camp, they face significant uncertainty following a tumultuous offseason that saw key players like Deebo Samuel depart. Key storylines include the integration of new receivers, ensuring player health—especially for Christian McCaffrey and Brock Purdy, who signed a lucrative contract—adapting rookies into the defense, and the stability of the offensive line amid roster changes. Need More Context? 🔎
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