The NFL’s 2025 schedule features several notable quirks, including the Los Angeles Chargers traveling the most miles (37,086) with games in Brazil and six in the Eastern time zone, while the Philadelphia Eagles have no back-to-back home games and play on five different weekdays. The Dallas Cowboys make history with four Thursday night games, and the Minnesota Vikings will play in consecutive international games. Additionally, the New Orleans Saints are without prime-time games for the first time since 2000, and intriguing matchups include a potential first game between left-handed quarterbacks since 2006.